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Tumor Necrosis Factor Alpha (TNF-alpha)

Tumor Necrosis Factor Alpha (TNF-alpha)

Cat no: T9160-15D

Supplier: United States Biological
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Tumor necrosis factor-alpha (TNF-alpha), a homotrimeric 17kD protein, is a potent mediator of inflammatory and metabolic functions. TNF-alpha was originally detected as a highly cytotoxic cytokine for tumor cells. It causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Further TNF-alpha has been implied as central mediator in shock induced by gram negative microorganisms. The cytokine TNF-alpha is found to be a central mediator in many inflammatory and immunological processes: it can be induced by various products of microorganisms and by various cytokines, but it also induces on its turn the production of many cytokines. Signal transduction occurs via two types of TNF-receptors, the TNF-receptors I and II. The receptors differ strongly in their intracellular signaling pathways. The TNF-alpha trimer interacts with either of the two types of TNF-R leading to receptor crosslinking. Applications: Suitable for use in ELISA and Neutralization. Other applications not tested. Recomended Dilutions: Optimal dilutions to be determined by the researcher. Affinity Constant: 5.7x10e-10M Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T9160-15D
Reactivities: Human, Bovine, Canine, Non-Human Primate
Hosts: Mouse
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.1% BSA.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Petyovka, N., et al., J. Immunol. Methods 186: 161 (1995). 2. Song, X., et al., J. Infect. Dis. 185: 204 (2002).
Additional info: Recognizes human Tumor Necrosis Factor alpha (TNF-alpha). Species Crossreactivity: Crossreacts and neutralizes all monkey species TNF-alpha, except pig-tail macaque. With affinity about two orders lower it recognizes bovine and canine TNF-alpha.

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