Tumor Necrosis Factor alpha (TNF alpha, TNF-alpha, TNF a, TNFa, TNF-a, Cachectin, Differentiation Inducing Factor, DIF, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF Superfamily Member 2, TNFSF2)

Tumor Necrosis Factor alpha (TNF-alpha) is a cytokine which has diverse immunomodulatory, anti-tumor and toxic effects. TNF-alpha has been detected in diverse inflammatory status and appears to be a critical mediator in the lethality of septic shock. Furthermore, TNF-alpha has also been found in inflammatory foci such as synovial effusions in rheumatoid arthritis, systemic circulation in septic shock, parasitemia and rejection of renal transplants.\n\nApplications:\nSuitable for use ELISA, Western Blot and Neutralization. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 1:20\nNeutralization: Inhibits ~50ug TNFa per ml.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T9160-03Q

Size

500ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, NHP

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

Additional Info

Recognizes natural and recombinant human Tumor Necrosis Factor alpha. Inhibits the biological activity of natural and recombinant human Tumor Necrosis Factor alpha as determined with L929 and WEHI cells in a cytotoxicity assay. Does not crossreact with human lymphotoxin. Species Crossreactivity: Cynomolgus monkey, and Rhesus monkey

Alternative Names

APC1, Macrophage Cytotoxic Factor, MCF, Necrosin, TNF Macrophage-derived, TNF Monocyte-derived, Tumor Necrosis Factor Precursor