Tumor Necrosis Factor alpha (TNF alpha, TNF-alpha, TNFalpha, TNFa, TNF-a, Cachectin, Differentiation Inducing Factor, DIF, MGC151434, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF Superfamily Member 2, TNFSF2)

Tumor Necrosis Factor alpha (TNF-alpha) is a cytokine which has diverse immunomodulatory, anti-tumor and toxic effects. TNF-alpha has been detected in diverse inflammatory status and appears to be a critical mediator in the lethality of septic shock. Furthermore, TNF-alpha has also been found in inflammatory foci such as synovial effusions in rheumatoid arthritis, systemic circulation in septic shock, parasitemia and rejection of renal transplants. The antibody shows neutralizing activity.\n\nApplications: \nSuitable for use in inhibition of biological activity and FACS analysis. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T9160-03V

Size

100ug

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in 0.1% BSA.

P Type

Mab

Purity

Purified

Isotype

IgD

References

1.Echtenacher, B. et al., Requirements of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis, J.Immunol. 1990, 145: 3762-3766. 2.Obermeier, F. et al., Interferon-gamma (IFN-gamma) and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice. Clin. Exp. Immunol. 1999, 116: 238-245.

Additional Info

Recognizes mouse TNFa. Reacts with both natural and recombinant TNFa and shows neutralizing activity.

Alternative Names

Tnfsf1a