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Tumor Necrosis Factor alpha (TNFa)

Tumor Necrosis Factor alpha (TNFa)

Cat no: T9160-04T

Supplier: United States Biological
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Tumor necrosis factor is a multifunctional proinflammatory cytokine, with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. Tumor necrosis factor-alpha (TNF-alpha), the product of activated monocytes, is secreted by macrophages in response to inflammation, infection and cancer (1). TNF-alpha triggers a signaling cascade, converging on the activation of the transcription factor NF-kappa B, which forms the basis for numerous physiological and pathological processes (2). TNF-alpha has been shown to play a role in systems such as the pathogenesis of psoriasis, tuberculosis, obesity, cerebral malaria, rheumatoid arthritis and asthma (3). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: T9160-04T
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine (pH 7.4), 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
Alternative names: TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin
References: 1.Brenner DA, et al., Nature (6208):661-3, 1989.2.Bouwmeester T, et al, Nat Cell Biol (2):87-9, 2004.3.Dbaibo GS, et al, J Biol Chem (24):17762-17766, 1993
Additional info: Recognizes human TNF alpha.

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