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Tumor Necrosis Factor alpha (TNFa, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, Cachectin, TNF, TNFA, TNFSF2)

Tumor Necrosis Factor alpha (TNFa, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, Cachectin, TNF, TNFA, TNFSF2)

Cat no: T9160-13J

Supplier: United States Biological
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Tumor Necrosis Factor alpha (TNFa) is a 17kD cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4+ T cells. TNF alpha forms dimers and trimers, and is also found as a 26kD integral membrane protein. Mouse TNF alpha has cytolytic activity against many tumor cell lines, and has an important immunoregulatory role. Applications: Suitable for use in ELISA, Flow Cytometry, and Immunohistochemistry. Other applications not tested. Recommended Dilutions: ELISA: 1-10ug/ml Flow Cytometry: 1:10-1:50; 10ul labels 10e6 cells in 100ul. Membrane permeabilization is required. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T9160-13J
Reactivities: Mouse, Rat
Hosts: Rat
Applications: ELISA, Flow Cytometry, Immunohistochemistry
Size: 500ug
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Abrams, J. S. et al. (1992) Immunol. Rev. 127: 5-24. 2. Hostager, B. et al. (2002) J. Immunol. 168:3318-3322. 3. Ross, S. et al. (1997) J. Immunol. 159:6253-6259. 4. Scanga, C. et al. (1999) Infect. Immun. 67:4531-4538. 5. Yang, J. et al. (1995) J. Immunol. 155:5728-5735. 6. Ruan, L., et al. (2009) Curr Alzheimer Res. 6:531-540.
Additional info: Recognizes mouse Tumor Necrosis Factor alpha. Reported to neutralize the effects of mouse TNFa. Species Crossreactivity: rat

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