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Tumor Necrosis Factor alpha, variant, Recombinant, Human (TNFa-variant)

Cat no: T9160-10G

Tumor Necrosis Factor alpha, variant, Recombinant, Human (TNFa-variant)

The clinical use of the potent antitumor activity of TNF-a has been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-a mutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-a, which binds to the murine TNF-R55 but not to the murine TNF-R75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-a, which binds to both murine TNF receptors. Based on these results, many TNF-amutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo.\n\nBiological Activity: \nFully biologically active when compared to standard. The Specific Activity is (same/more than)1.0

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SPECIFICATIONS

Catalog Number

T9160-10G

Size

10ug

Form

Supplied as a lyophilized powder in PBS, pH 7.5. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1mg/ml.

Purity

~95% by SDS-PAGE and HPLC analyses.

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