Home  >  Products  >  Tumor Necrosis Factor beta (TNFb, Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA, TNFB, TNFSF1)
Tumor Necrosis Factor beta (TNFb, Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA, TNFB, TNFSF1)

Tumor Necrosis Factor beta (TNFb, Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA, TNFB, TNFSF1)

Cat no: T9160-43

Supplier: United States Biological
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TNF beta, also known as lymphotoxin alpha (LT-alpha), is a homotrimeric polypeptide secreted by activated T and B lymphocytes, which binds to the TNF receptors TNFR1, TNFR2 and HVEM (herpes virus entry mediator receptor). TNF-beta was originally isolated due to its cytotoxic effects on tumor cells, and has since been identified as a regulator of many cellular processes and a potent mediator of inflammation and immune responses against invading pathogens. Applications: Suitable for use in Immunofluorescence. Other applications not tested. Recommended Dilution: Immunofluorescence: 2-10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T9160-43
Reactivities: Human
Hosts: Mouse
Applications: Immunofluorescence
Size: 100ug
Form: Supplied as a liquid, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
References: 1. Pfeffer, K. (2003) Biological functions of tumor necrosis factor cytokines and their receptors. Cytokine Growth Factor Rev. 14: 185-191.
Additional info: Recognizes both the natural and recombinant forms of human TNF beta. It can be used to stain TNF beta producing cells, using immunoperoxidase or immunofluorescence techniques.

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