TWEAK, Recombinant, Human (TNF-related Weak Inducer of Apoptosis, APO3 Ligand, APO3/DR3 Ligand, APO3L, CD255, DR3LG, FN14, HCG1991317, MGC129581, MGC20669, Tumor Necrosis Factor Ligand Superfamily Member 12, TNFSF12, UNQ181/PRO207)

Human TWEAK is a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. TWEAK, like many members of the TNF family, was able to induce interleukin-8 synthesis in a number of cell lines. Recombinant Human TWEAK is a 17.0kD protein, comprising the TNF-like extracellular domain of TWEAK. \n\nSource: E.coli \n\nForm: The sterile filtered solution was lyophilized from 10mM sodium phosphate, pH 7.5, 0.1M L-Arg. \n\nPurity: (same/more than) 98% by SDS-PAGE and HPLC.\n\nEndotoxin: (same/less than) 0.1ng/ug (1EU/ug)\n\nBiological Activity: The ED50 as determined by the dose-dependent stimulation of IL-8 production by Human PBMC (peripheral blood mononuclear cells) is less than 10ng/ml. \n\nAA Sequence: MKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SATAASSLGP QLRLCQVSGL LALRPGSSLR IRTLPWAHLK AAPFLTYFGL FQVH\n\nReconstitution: We recommend a quick spin followed by reconstitution in 10mM sodium phosphate pH 7.5 to a concentration of 1mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4 degrees C for 1 week or at -20 degrees C for future use. \n\nStability: Lyophilized protein is stable for a few weeks at room temperature, but best at -20 degrees C. Reconstituted TWEAK should be stored in working aliquots at -20 degrees C. \n\nCountry of Origin: USA

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts