Tyk2, Active, Recombinant, Human, His-Tag (Non-receptor Tyrosine-protein Kinase TYK2)

TYK2 belongs to the Jak family of nonreceptor tyrosine kinases which includes four mammalian members, Jak1 to 3 and TYK2. Jaks play a pivotal role in signaling via a number of cytokines and growth hormones. Jaks associate with the intracellular domains of cytokine receptors and become phosphorylated upon ligand binding. Activated Jaks phosphorylate tyrosine residues of the respective receptor chains, which, in turn, leads to the recruitment and subsequent phosphorylation of STATs. Phosphorylated STAT proteins form homo- and/or heterodimers, translocate to the nucleus, and regulate cytokine-responsive genes. TYK2 initially identified by its essential role in type I IFN signaling, was subsequently shown to be involved in signaling via a number of other cytokines. Studies of human cell lines also revealed structural functions of Tyk2 for transport and stabilization of the IFNAR1. Human TYK2 gene is mapped to chromosomal region 19p13.2.\n\nSource:\nRecombinant corresponding to aa871-1187 from human Tyk2, fused to His-tag at N-terminal, expressed in a Baculovirus-infected Sf9 cell expression system.\n\nMolecular Weight:\n~38kD\n\nApplications:\nSuitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

137387

Size

10ug

Form

Supplied as a liquid in 45mM Tris, pH 8, 125mM sodium chloride, 2.4mM potassium chloride, 0.045% Tween-20, 100mM imidazole, 10% glycerol.

Purity

Highly Purified (~95%)

References

1. Firmbach-Kraft I, et al. (1990). Oncogene 5 (9): 1329-36. 2. Partanen J, et al. (1991Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8913-7. 3. Domanski P, et al. (1995). FEBS Lett. 374 (3): 317-22.