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TYK2 (Tyrosine Kinase 2, JTK1, Non-receptor Tyrosine Protein Kinase 2, Non-receptor Tyrosine Protein Kinase TYK2, Protein Tyrosine Kinase 2)

Cat no: T9220-01H

TYK2 (Tyrosine Kinase 2, JTK1, Non-receptor Tyrosine Protein Kinase 2, Non-receptor Tyrosine Protein Kinase TYK2, Protein Tyrosine Kinase 2)

TYK2 belongs to the Jak family of nonreceptor tyrosine kinases which includes four mammalian members, Jak1 to 3 and TYK2. Jaks play a pivotal role in signaling via a number of cytokines and growth hormones. Jaks associate with the intracellular domains of cytokine receptors and become phosphorylated upon ligand binding. Activated Jaks phosphorylate tyrosine residues of the respective receptor chains, which, in turn, leads to the recruitment and subsequent phosphorylation of STATs. Phosphorylated STAT proteins form homo- and/or heterodimers, translocate to the nucleus, and regulate cytokine-responsive genes. TYK2 initially identified by its essential role in type I IFN signaling, was subsequently shown to be involved in signaling via a number of other cytokines. Studies of human cell lines also revealed structural functions of Tyk2 for transport and stabilization of the IFNAR1. Human TYK2 gene is mapped to chromosomal region 19p13.2.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T9220-01H

Size

100ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Birgit, S. et al. The Journal of Immunology. 175:4000-4008 (2005).

Additional Info

Recognizes human TYK2. Species Crossreactivity: mouse and rat.

Alternative Names

EC=2.7.10.2

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