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TYK2 (V1048) pAb

TYK2 (V1048) pAb

Cat no: BS3713

Supplier: Bioworld Technology, Inc.
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Tyk 2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where Tyk 2 is associated. Tyk 2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.
Catalogue number: BS3713
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P29597
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 1010-1065 of Human TYK2.
Species: Tyk 2 (V1048) pAb detects endogenous levels of Tyk 2 protein.
Molecular weight: ~ 134 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: JTK 1; Protein Tyrosine Kinase 2; JTK 1; Protein Tyrosine Kinase 2; TYK 2; Tyrosine kinase 2; JTK1; Non receptor tyrosine protein kinase TYK2; Non receptor tyrosine protein kinase 2
Additional info: For research use only, not for use in diagnostic procedure.

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