Tyrosine Hydroxylase, phorphorylated (SER19) (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase)

Tyrosine hydroxylase catalyses the rate-limiting step in the biosynthetic pathway of the catecholamines dopamine (DA), norepinephrine, and epinephrine. The enzyme exists as a tetramer, with each subunit composed of an N-terminal regulatory domain and a C-terminal catalytic domain.\nTyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson

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SPECIFICATIONS

Catalog Number

T9237-06C

Size

100ul

Applications

FC, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in 10mM HEPES, pH 7.5, 0.1% BSA, 0.09% BSA and 50% glycerol.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

References

1. Bevilaqua, L.R.M. et al. (2001). Phosphorylation of Ser19 Alters the Conformation of Tyrosine Hydroxylase to Increase the Rate of Phosphorylation of Ser40. J. Biol. Chem. 276: 40411 - 40416. 2. Haycock, J.W. et al. (1990). Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40. J. Biol. Chem. 265: 11682 - 11691. 3. Lew, J.H. et al. (1999). Increased Site-Specific Phosphorylation of Tyrosine Hydroxylase Accompanies Stimulation of Enzymatic Activity Induced by Cessation of Dopamine Neuronal Activity. Mol. Pharmacol. 55: 202 - 209.

Additional Info

Specific for Tyrosine Hydroxylase, when phosphorylated at serine 19.\nSpecies Cross Reactivity: Human, mouse and rat.