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Tyrosine Hydroxylase (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase)

Tyrosine Hydroxylase (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase)

Cat no: T9237-21C

Supplier: United States Biological
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Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. TH has a large molecular diversity, resulting from differential splicing of its mRNA, which is tissue specific and might result in long term changes in activity of the enzyme and its availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: PC-12 cells stimulated by okadaic acid Cellular Localization: Can be used as a marker for dopaminergic and noradrenergic neurons. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T9237-21C
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: 10 HEPES [pH7.5], 150 mM NaCl, & 100ug/ml BSA with 50% glycerol
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Haavik, J. and Toska, K. Tyrosine hydroxylase and Parkinson's disease. Mol. Neurobiology 16(3) :285-309, 1998. 2. Mallett, J. The TiPs/TINS lecture. Catecholamines from Gene Regulation to neuropsychiatric disorders. Trends in Pharmacological Science. 17(4): 129-135, 1996. 3. Kumer SC, Vrana, KE, Intricate regulation of tyrosine hydroxylase activity and gene expression. Journal of Neurochemistry, 67(2) :443-462, 1996. 4. Lewis DA, et al, Neuroscience 54: 477-, 1993 5. Haycock, J. Anal. Biochemistry 181: 259-266, 1989. 6. Haycock, J. Anal. Biochemistry 208: 397-399, 1993. 7. Renfroe, J.B., et al. Brain Res. Bull. 13: 109 - 126, 1984.
Additional info: Specific for tyrosine hydroxylase. Species Crossreactivity: Detects all mammalian forms of TH tested to date and some non-mammalian. Also detects some invertebrate forms of TH.

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