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Tyrosine Hydroxylase (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase)

Tyrosine Hydroxylase (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase)

Cat no: T9237-21E

Supplier: United States Biological
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Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore, the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. TH has a large molecular diversity, resulting from differential splicing of its mRNA, which is tissue specific and might result in long term changes in activity of the enzyme and its availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency, as low dopamine levels are a consistent neurochemical abnormality. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T9237-21E
Reactivities: Human, Mouse, Rat, Non-Human Primate, Porcine
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ul
Form: PBS (divalent-deficient) containing 10% glyverol, 10 mM HEPES [pH 7.2], 20 mM Tris-HCl [pH 7.6], 1 m
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Alternative names: TH, Tyrosine hydroxylase, Tyrosine 3-monooxygenase, L-tyrosine hydroxylase, Tyrosine 3-hydroxylase
References: 1. Salvatore, MF, et al. Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. J. Neurochem., 75: 225-232. 2000 2. Lew, JY, et al. Increased site-specific phosphorylation of tyrosine hydroxylase accompanies stimulation of enzymatic activity induced by cessation of dopamine neuronal activity. Mol. Pharm., 55: 202-209. 1998 3. Witkovsky, P, et al. Influence of light and neural circuitry on tyrosine hydroxylase phosphorylation in the rat retina. J. Chem. Neuroanat., 19: 105-116. 2000
Additional info: Specific for the 60kD Tyrosine Hydroxylase phosphorylated at Ser40. Species Crossreactivity: Rat, human, porcine, quail, monkey and mouse.

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