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Tyrosine Hydroxylase (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase)

Tyrosine Hydroxylase (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase)

Cat no: T9237-21M

Supplier: United States Biological
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The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:8000 Western Blot: 2-4ug/ml ~55kD band observed in Human Brain (Cerebral Cortex) lysates (calculated MW of 55.5kD according to NP_000351.2) Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T9237-21M
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: tyrosine 3-monooxygenase, dystonia 14, DYT5b, DYT14, TYH, HGNC:11782, tyrosine hydroxylase, TH
References: 1.Voeller KK. Attention-deficit hyperactivity disorder (ADHD).J Child Neurol. 2004 Oct;19(10):798-814
Additional info: Recognizes human Tyrosine Hydroxylase. This antibody is expected to recognise all three reported isoforms (as represented by NP_954986.2; NP_000351.2; NP_954987.2). Species sequence homology: rat, canine.

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