Supplier:
Alomone Labs Ltd.Cat no: U-400
U0126
0126пїЅis a chemically synthesized organic compound that was initially recognized as a cellular AP-1 antagonist, and found to be a very selective and highly potent inhibitor of Mitogen-Activated ProteinпїЅKinase (MAPK) cascade by inhibiting its immediate upstream activators, Mitogen Activated Protein Kinase Kinase 1and 2 (also known as MEK1 and MEK2, IC50: 70 and 60 nM respectively). U0126 inhibits both active and inactive MEK1,2, unlike PD098059 which only inhibits activation of inactive MEK (1,2). Blockade of MEKпїЅactivation would prevent downstream phosphorylation of a number of factors including p62TCF (Elk-1), an upstream inducer of c-Fos and c-Jun, components of the AP-1 complex. Inhibition of MEK/ERK pathway by U0126 also prevents all effects of oncogenic H-Ras and K-Ras, inhibits part of the effects triggered by growth factors and blocks the production of inflammatory cytokines and matrix metalloproteinases. Protein Kinase Inhibitors and Activators; MAPK and MAPK Homolog Inhibitors
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SPECIFICATIONS
Catalog Number
U-400
Size
1 mg
Purity
>99%
Concentration
0.1-100 micro M
Shipping Temp
Room Temperature
Molecular Weight
380.5
SUPPLIER INFO
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