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U1-70K, Apoptotic Cleavage Product (U1 Small Nuclear Ribonucleoprotein 70kD, U1 snRNP 70kD, NPU1Z, RNPU1Z, RPU1, RSNRP70, Snp1, snRNP70, SNRP70, U1AP, U1AP1, U170K, U1RNP)

Cat no: U0004-70B

U1-70K, Apoptotic Cleavage Product (U1 Small Nuclear Ribonucleoprotein 70kD, U1 snRNP 70kD, NPU1Z, RNPU1Z, RPU1, RSNRP70, Snp1, snRNP70, SNRP70, U1AP, U1AP1, U170K, U1RNP)

All components of the U1 snRNP complex, including the U1-70K protein, are important autoantigens in patients with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). Anti-apoptotic cleavage product of human U1-70K.\n\nApplications:\nSuitable for use in Western Blot and ELISA Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

U0004-70B

Size

100ug

Applications

ELISA

Reactivities

Hum

Form

Supplied as a liquid in 100mM Tris-HCl, pH 8.0, 0.05% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1,l

References

1. Hof, D., Cheung, K., de Rooij, D.R.A.M., van den Hoogen, F.H., Pruijn, G.J.M., van Venrooij, W.J., and J.M.H. Raats. (2005). Autoantibodies specific for apoptotic U1-70K are superior serological markers for mixed

Additional Info

Recognizes human U1-70K. Specifically bound to stemloop I of the U1 small nuclear RNA contained in the U1 small nuclear ribonucleoprotein complex (U1 snRNP), which is\ninvolved in the splicing of pre-mRNA.

Alternative Names

Small Nuclear Ribonucleoprotein 70kDa (U1)

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