$U73122\n1-(6-(17b-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione$

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Cat no: U0550

U73122\n1-(6-(17b-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione

U73122 inhibits agonist induced phospholipase C (PLC) activation in human platelets and neutrophils. This compound also inhibits agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. U73122 is a useful tool for investigating\nreceptor-mediated PI turnover in signal transduction and is a potent inhibitor of human neutrophil adhesion to biological surfaces, as well as adhesion-dependent granule exocytosis and oxidative burst.\n\nBiological Activity: IC50 = 1.0-2.1uM (agonist induced PLC activation in human platelets and neutrophils)\n\nSolubility: Soluble in chloroform; soluble in methylene chloride; soluble in DMSO at a concentration of 2mg/ml; and soluble in ethanol at a concentration of 1mg/ml.\n\nSuggested Reconstitution: Because U73122 is only slightly soluble in aqueous media, it is best delivered to cells either when dissolved in organic solvents or when complexed with serum proteins. The following methods of reconstitution and delivery to cells are recommended.\nMethod 1:\n1. U73122 may be dissolved directly in ethanol or DMSO immediately prior to use. Unused portions may be stored at

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SPECIFICATIONS

Catalog Number

U0550

Size

5mg

Form

Off-white, lyophilized powder

Purity

~98% (TLC)

References

1. Smith, R.J., et al., J. Pharmacol. Exp. Ther. 253: 688-697 (1990). 2. Bleasdale, J.E., et al., J. Pharmacol. Exp. Ther. 255(2): 756-768 (1990). 3. Lockhart, L.K. & McNicol, A., J. Pharmacol. Exp. Ther. 289(2): 721-728 (1999). 4. Dittmar, T., et al., FASEB J. 16(13): 1823-1825 (2002). 5. Maddens, S., et al., Blood 100(4): 1294-1301 (2002). 6. Vossmeyer, D., et al., J. Biol. Chem. 277(7): 4636-4643 (2002).

Alternative Names

1-(6-(17b-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione