The U-937 cell line was derived by Sundstrom and Nilsson in 1974 from malignant cells obtained from pleural effusion from a patient with histiocytic lymphoma; studies since 1979 have shown that U-937 cells can be induced to terminal monocytic differentiation by supernatants from human mixed lymphocyte cultures, by phorbol esters, by vitamin D3 by gamma interferon, by tumor necrosis factor (TNF) and by retinoic acid; the cells are negative for immunoglobulin production and Epstein-Barr virus expression.
Receptor Expression: complement (C3)
Genes Expressed: lysozyme; beta-2-microglobulin (beta 2 microglobulin); tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid (PMA)
Products: lysozyme; beta-2-microglobulin (beta 2 microglobulin); tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid (PMA)
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