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UAP1 (UDP-N-acetylhexosamine Pyrophosphorylase, Antigen X, AGX, Sperm-associated Antigen 2, SPAG2)

Cat no: U0825-01

UAP1 (UDP-N-acetylhexosamine Pyrophosphorylase, Antigen X, AGX, Sperm-associated Antigen 2, SPAG2)

UAP1 is a 56kD isoform which catalyzes the final step of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis from fructose-6-phosphate. UDP-GlcNAc, the activated form of GlcNAc moiety is used as a key precursor in N-linked glycosylation and the glycosylphosphatidylinositol (GPI)-anchor of cellular proteins. Crystallization studies revealed UAP1 is composed of a large central core flanked by two smaller extra domains. The central main domain displays a

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SPECIFICATIONS

Catalog Number

U0825-01

Size

100ug

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum, Bov

Form

Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1. Diekman,A.B. and Goldberg,E. Characterization of a human antigen with sera from infertile patients. Biol. Reprod. 50 (5), 1087-1093 (1994). 2. Mio,T., Yabe,T., Arisawa,M. and Yamada-Okabe,H. The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism. J. Biol. Chem. 273 (23), 14392-14397 (1998). 3. Peneff. C et.al EMBO J. 20(22):6191-202 (2001 Nov 15).

Additional Info

Recognizes human UAP1. Species Crossreactivity: bovine. Species sequence homology: mouse, rat, canine.

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Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info
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