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UAP1 (UDP-N-acetylhexosamine Pyrophosphorylase, Antigen X, AGX, Sperm-associated Antigen 2, SPAG2)

Cat no: U0825-01


Supplier: United States Biological
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UAP1 is a 56kD isoform which catalyzes the final step of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis from fructose-6-phosphate. UDP-GlcNAc, the activated form of GlcNAc moiety is used as a key precursor in N-linked glycosylation and the glycosylphosphatidylinositol (GPI)-anchor of cellular proteins. Crystallization studies revealed UAP1 is composed of a large central core flanked by two smaller extra domains. The central main domain displays a
Catalogue number: U0825-01
Reactivities: Human, Bovine
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Diekman,A.B. and Goldberg,E. Characterization of a human antigen with sera from infertile patients. Biol. Reprod. 50 (5), 1087-1093 (1994). 2. Mio,T., Yabe,T., Arisawa,M. and Yamada-Okabe,H. The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism. J. Biol. Chem. 273 (23), 14392-14397 (1998). 3. Peneff. C et.al EMBO J. 20(22):6191-202 (2001 Nov 15).
Additional info: Recognizes human UAP1. Species Crossreactivity: bovine. Species sequence homology: mouse, rat, canine.

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