Home  >  Products  >  UBA6 (Ubiquitin-like Modifier-activating Enzyme 6, Ubiquitin-activating Enzyme 6, Monocyte Protein 4, MOP-4, Ubiquitin-activating Enzyme E1-like Protein 2, E1-L2, MOP4, UBE1L2)
UBA6 (Ubiquitin-like Modifier-activating Enzyme 6, Ubiquitin-activating Enzyme 6, Monocyte Protein 4, MOP-4, Ubiquitin-activating Enzyme E1-like Protein 2, E1-L2, MOP4, UBE1L2)

UBA6 (Ubiquitin-like Modifier-activating Enzyme 6, Ubiquitin-activating Enzyme 6, Monocyte Protein 4, MOP-4, Ubiquitin-activating Enzyme E1-like Protein 2, E1-L2, MOP4, UBE1L2)

Cat no: U1002-01A

Supplier: United States Biological
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Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1002-01A
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human UBA6. Species sequence homology: Bovine, chimpanzee, equine, mouse and rat.

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