Home  >  Products  >  UBA7 (Ube1L, Ubiquitin-like Modifier-activating Enzyme 7, Ubiquitin-activating Enzyme 7, D8, Ubiquitin-activating Enzyme E1 Homolog, UBE2)
UBA7 (Ube1L, Ubiquitin-like Modifier-activating Enzyme 7, Ubiquitin-activating Enzyme 7, D8, Ubiquitin-activating Enzyme E1 Homolog, UBE2)

UBA7 (Ube1L, Ubiquitin-like Modifier-activating Enzyme 7, Ubiquitin-activating Enzyme 7, D8, Ubiquitin-activating Enzyme E1 Homolog, UBE2)

Cat no: U1002-03A

Supplier: United States Biological
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Ube1L is a member of the E1 ubiquitin-activating enzyme family. It is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARa) degradation and apoptosis in acute promyelocytic leukemia. It has been reported that Ube1L acts as the activating enzyme in the ISG15 conjugation pathway. ISG15 is an ubiquitin-like protein and its transcription is induced by interferon treatment. Applications: Suitable for use in and Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 1:50 for 10min at RT Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10min followed by cooling at RT for 20min Optimal dilutions to be determined by the researcher. Positive Control: Normal lung Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1002-03A
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human Ube1L.

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