Home  >  Products  >  UBC1 (DKFZp564C1216, DKFZp686J24237, E2(25K), E2-25K, Huntingtin-interacting Protein 2, HIP 2, HIP2, HIP-2, HYPG, LIG, Ubiquitin Carrier Protein, Ubiquitin Conjugating Enzyme E2 25kD, Ubiquitin-conjugating Enzyme E2-25kD, Ubiquitin Protein Ligase)
UBC1 (DKFZp564C1216, DKFZp686J24237, E2(25K), E2-25K, Huntingtin-interacting Protein 2, HIP 2, HIP2, HIP-2, HYPG, LIG, Ubiquitin Carrier Protein, Ubiquitin Conjugating Enzyme E2 25kD, Ubiquitin-conjugating Enzyme E2-25kD, Ubiquitin Protein Ligase)

UBC1 (DKFZp564C1216, DKFZp686J24237, E2(25K), E2-25K, Huntingtin-interacting Protein 2, HIP 2, HIP2, HIP-2, HYPG, LIG, Ubiquitin Carrier Protein, Ubiquitin Conjugating Enzyme E2 25kD, Ubiquitin-conjugating Enzyme E2-25kD, Ubiquitin Protein Ligase)

Cat no: U0879-30A

Supplier: United States Biological
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HIP2 belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis. Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequent degradation of p53. Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: U0879-30A
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Kalchman MA et al. Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J Biol Chem 271:19385-94 (1996). PubMed: 8702625 Search PubMed (MEDLINE) for references to HIP2
Additional info: Species Crossreactivity: Reacts with Human.

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