Home  >  Products  >  UBE2K (Ubiquitin-conjugating Enzyme E2-25kD, Ubiquitin-protein Ligase, Ubiquitin Carrier Protein, E2(25K), Huntingtin Interacting Protein 2, HIP-2, Ubiquitin-conjugating Enzyme E2 K, HIP2, LIG)
UBE2K (Ubiquitin-conjugating Enzyme E2-25kD, Ubiquitin-protein Ligase, Ubiquitin Carrier Protein, E2(25K), Huntingtin Interacting Protein 2, HIP-2, Ubiquitin-conjugating Enzyme E2 K, HIP2, LIG)

UBE2K (Ubiquitin-conjugating Enzyme E2-25kD, Ubiquitin-protein Ligase, Ubiquitin Carrier Protein, E2(25K), Huntingtin Interacting Protein 2, HIP-2, Ubiquitin-conjugating Enzyme E2 K, HIP2, LIG)

Cat no: U0879-30D

Supplier: United States Biological
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HIP2 belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:2000 Western Blot: 1-3ug/ml, observed in Jurkat cell lysates on ~24kD bands Immunohistochemistry (Paraffin): 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U0879-30D
Reactivities: Human, Mouse, Bovine, Canine, Porcine
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR. Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J Biol Chem. 1996 Aug 9;271(32):19385-94.
Additional info: Recognizes human UBE2K. Species sequence homology: Bovine, canine, mouse and porcine.

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