Home  >  Products  >  Ubiquitin Activating Enzyme 6 (Ubiquitin-like Modifier-activating Enzyme 6, UBA6, E1-L2, FLJ10808, FLJ23367, Monocyte Protein 4, MOP4, MOP-4, Ubiquitin-activating Enzyme E1-like Protein 2, UBE1L2)
Ubiquitin Activating Enzyme 6 (Ubiquitin-like Modifier-activating Enzyme 6, UBA6, E1-L2, FLJ10808, FLJ23367, Monocyte Protein 4, MOP4, MOP-4, Ubiquitin-activating Enzyme E1-like Protein 2, UBE1L2)

Ubiquitin Activating Enzyme 6 (Ubiquitin-like Modifier-activating Enzyme 6, UBA6, E1-L2, FLJ10808, FLJ23367, Monocyte Protein 4, MOP4, MOP-4, Ubiquitin-activating Enzyme E1-like Protein 2, UBE1L2)

Cat no: U1002-02

Supplier: United States Biological
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UBE1L2 is a novel E1 enzyme specific for ubiquitin and belongs to the ubiquitin-activating E1 family. It is a part of the cascade to attach ubiquitin (Ub) covalently to substrate proteins. It activates ubiquitin by first adenylating its carboxy-terminal glycine residue with ATP and then linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Its isoforms influence spermatogenesis and male fertility. It is highly expressed in human monocytes. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Daudi and RAW cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1002-02
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Jin, J. et al. Nature. 447:1135-1138 (2007). 2. Pelzer, C. et al. J. Biol. Chem. 282:23010-23014 (2007).
Additional info: Recognizes human UBE1L2/MOP-4. Species Crossreactivity: chimpanzee. Species sequence homology: bovine, equine, mouse, rat.

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