Home  >  Products  >  Ubiquitin Activating Enzyme E1 (Ubiquitin-activating Enzyme E1, UBE1, A1S9, A1S9 Protein, A1S9T and BN75 Temperature Sensitivity Complementing, A1S9T, A1ST, AMCX1, GXP1, MGC4781, SMAX2, UBE1X)
Ubiquitin Activating Enzyme E1 (Ubiquitin-activating Enzyme E1, UBE1, A1S9, A1S9 Protein, A1S9T and BN75 Temperature Sensitivity Complementing, A1S9T, A1ST, AMCX1, GXP1, MGC4781, SMAX2, UBE1X)

Ubiquitin Activating Enzyme E1 (Ubiquitin-activating Enzyme E1, UBE1, A1S9, A1S9 Protein, A1S9T and BN75 Temperature Sensitivity Complementing, A1S9T, A1ST, AMCX1, GXP1, MGC4781, SMAX2, UBE1X)

Cat no: U1000-08C

Supplier: United States Biological
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Ubiquitinylation, the covalent attachment of ubiquitin to protein, regulates a number of cellular processes including responses to stress. This process is responsible for selective targeting of proteins for degradation. The first step in ubiquitinylation is the activation of ubiquitin by ubiquitin activating enzyme E1 which is a rate-limiting enzyme in the conjugation process. The ubiquitin activating enzyme exists as two isoforms: E1a (117kD), localized predominantly in the nucleus, and E1b (110kD), localized in the cytoplasm. The first 11 amino acids are considered to be essential for phosphorylation and exclusive nuclear localization of the enzyme. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: U1000-08C
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ug
Form: 0.15M Sodium chloride, 0.02M Potassium phosphate.
P type: Pab
Isotype: IgG
Purity: Serum
Additional info: Species Crossreactivity: Reacts with Human. Predicted to react with Mouse (95% identity with immunogen), Rat (95% identity with immunogen), Rabbit (96% identity with immunogen) and canine (93% identity with immunogen) due to sequence homology.

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