Home  >  Products  >  Ubiquitin Hydrolase L1, CT (PGP9.5, Ubiquitin CT Hydrolase L1, UCH, UCHL1, Ubiquitin thiolesterase, PARK5)
Ubiquitin Hydrolase L1, CT (PGP9.5, Ubiquitin CT Hydrolase L1, UCH, UCHL1, Ubiquitin thiolesterase, PARK5)

Ubiquitin Hydrolase L1, CT (PGP9.5, Ubiquitin CT Hydrolase L1, UCH, UCHL1, Ubiquitin thiolesterase, PARK5)

Cat no: U1005D

Supplier: United States Biological
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UCHL1 is a thiol protease that catalyzes the hydrolysis of C-terminal of ubiquityl esters and amides to generate ubiquitin monomer. It also binds to free monomer and may prevent its degradation by lysosomes. It is expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. UCHL1 oxidation has been observed in brains of patiens with Alzheimer's and Parkinson's diseases. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: U1005D
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 1mg
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Purity: Purified by Protein G affinity chromatography.
References: Day, I.N. e. al. (1990) Biochem. J. 268,521 - 524. Solano, S.M. et al. (2000) Ann. Neurol 47,201 -210. Liu, Y. et. al. (2002) Cell 111,209 -218. Nishikawa, K. et al. (2003) Biochem. Biophys. Res. Commun. 304,176 - 183.
Additional info: Recognizes human UCHL1

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