Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), also known as PGP 9.5, is a neuronal and neuroendocrine-specific protein that plays a role in proteosomal protein degradation, which is critical for neuronal health. UCH-L1 is also involved in p27kip1 degradation through its interaction and nuclear translocation with JAB1. UCH-L1 expression is specifically associated with non small-cell lung cancer development and it is found in serum of patients with lung cancer, indicating that it may be important in lung cancer screening and diagnosis. UCH-L1 may also be a useful marker for invasive colorectal cancer. Mutations in the alpha-synuclein and Uch-L1 genes cause autosomal dominant Parkinson's disease (PD). Derangements in the ubiquitin proteasomal pathway may play important roles in the demise of dopamine neurons in PD.
Applications:
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Western Blot: 1:2000
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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