Home  >  Products  >  UCHL1 (Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1, UCH-L1, Neuron Cytoplasmic Protein 9.5, PGP 9.5, PGP9.5, Ubiquitin Thioesterase L1)

UCHL1 (Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1, UCH-L1, Neuron Cytoplasmic Protein 9.5, PGP 9.5, PGP9.5, Ubiquitin Thioesterase L1)

Cat no: U1005-01G3


Supplier: United States Biological
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Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), also known as PGP 9.5, is a neuronal and neuroendocrine-specific protein that plays a role in proteosomal protein degradation, which is critical for neuronal health. UCH-L1 is also involved in p27kip1 degradation through its interaction and nuclear translocation with JAB1. UCH-L1 expression is specifically associated with non small-cell lung cancer development and it is found in serum of patients with lung cancer, indicating that it may be important in lung cancer screening and diagnosis. UCH-L1 may also be a useful marker for invasive colorectal cancer. Mutations in the alpha-synuclein and Uch-L1 genes cause autosomal dominant Parkinson
Catalogue number: U1005-01G3
Reactivities: Human, Mouse, Rat
Hosts: Sheep
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human UCH-L1. Species Crossreactivity: mouse, rat.

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