Home  >  Products  >  UGRP2, Recombinant, Mouse (Secretoglobin Family 3A Member 1, Cytokine HIN-1, High in Normal 1, Pneumo Secretory Protein 2, PnSP-2, Uteroglobin-related Protein 2, HIN1, PNSP2, SCGB3A1, UNQ629/PRO1245)
UGRP2, Recombinant, Mouse (Secretoglobin Family 3A Member 1, Cytokine HIN-1, High in Normal 1, Pneumo Secretory Protein 2, PnSP-2, Uteroglobin-related Protein 2, HIN1, PNSP2, SCGB3A1, UNQ629/PRO1245)

UGRP2, Recombinant, Mouse (Secretoglobin Family 3A Member 1, Cytokine HIN-1, High in Normal 1, Pneumo Secretory Protein 2, PnSP-2, Uteroglobin-related Protein 2, HIN1, PNSP2, SCGB3A1, UNQ629/PRO1245)

Cat no: U7001-21

Supplier: United States Biological
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High in Normal-1 also known as Uteroglobulin related protein 2 (UGRP2), is an 8kD secreted protein of the secretoglobin superfamily (SCGB3A1). HIN-1 is expressed in bronchial epithelial and secretory Clara cells, mammary epithelial cells (particularly during pregnancy), salivary glands, and the prostate. It is up-regulated in Clara cells by IL-4, IL-13, Oncostatin M, EGF, and TGF-a and down-regulated by IFNa B, and g. It is secreted into bronchial lavage fluid, saliva, and plasma and may form disulfide-linked dimers. HIN-1 binds to the macrophage scavenger receptor MARCO and to the surface of mammary and bronchial epithelial cells. HIN-1 promotes apoptosis and inhibits the proliferation, migration, and invasion of breast cancer cells likely through the Akt signaling pathway. The down-regulation of HIN-1 expression in many breast, lung, and prostate cancers correlates with hypermethylation of its promoter. Mature mouse HIN-1 shares 58% and 93% aa sequence identity with human and rat HIN-1, respectively. A variant of mouse HIN-1 has a substitution at the N-terminus in place of its potential signal peptide. Source: Recombinant corresponding to aa22-104 from mouse HIN-1expressed in E.coli. Molecular Weight: ~8.4kD Activity: Measured by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cell line. The ED50 for this effect is typically 0.5-2.5ug/ml Endotoxin: ~1EU/1ug (LAL) Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: U7001-21
Size: 50ug
Form: Supplied as a lyophilized powder in PBS. BSA free. Reconstitute with sterile PBS to 0.25mg/ml.
Purity: ~95% (SDS-PAGE)
References: 1. Mukherjee, A.B. et al. (2007) Endocr. Rev. 28:707. 2.Porter, D. et al. (2002) Mech. Dev. 114:201. 3. Reynolds, S.D. et al. (2002) Am. J. Respir. Crit. Care Med.166:1498. 4. Krop, I. et al. (2001) Proc. Natl. Acad. Sci. 98:9796. 5. Niimi, T. et al. (2002) Cytogenet. Genome Res. 97:120. 6. Yamada, A. et al. (2005) J. Immunol. 175:5708. 7.Tomita, T. et al. (2009) Am. J. Respir. Cell Mol. Biol. 40:620. 8. Yamada, A. and S. Kimura (2005) FEBS Lett. 579:2221. 9. Yamada, A. et al. (2009) Biochem. Biophys. Res. Commun. 379:964. 10. Krop, I. et al. (2004) Mol. Cancer Res. 2:489. 11. Bin, L.-H. et al. (2003) J. Immunol. 171:924. 12. Krop, I. et al. (2005) Cancer Res. 65:9659. 13. Krop, I. et al. (2003) Cancer Res. 63:2024. 14. Shigematsu, H. et al. (2005) Int. J. Cancer 113:600.

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