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Ugt2b (UDP Glycosyltransferase 2 Family Polypeptide B)

Ugt2b (UDP Glycosyltransferase 2 Family Polypeptide B)

Cat no: U0825-42

Supplier: United States Biological
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The UDP-glucuronosyltransferases (UGTs, EC 2.4.1.17) comprise a large family of proteins capable of detoxifying a wide variety of both endogenous and exogenous substrates. The primary function of this gene superfamily is to catalyze the glycosylation of substrates such as biogenic amines, steroids, bile acids, phenolic compounds and various other pharmacologically relevant compounds, including numerous carcinogens, toxic environmental pollutants and prescription drugs. This conjugation increases the solubility of these compounds, allowing them to be excreted more readily through hepatic or renal mechanisms Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.1-0.3ug/ml, observed in rat kidney lysates on ~50kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U0825-42
Reactivities: Rat
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: General References: Pharmacogenetics. 2000 Apr;10(3):251-60. Genomic organization of the UGT2b gene cluster on human chromosome 4q13
Additional info: Recognizes rat Ugt2b.

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