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Ultra-LEAF(TM) Purified anti-mouse IL-27 p28

Ultra-LEAF(TM) Purified anti-mouse IL-27 p28

Cat no: 516912

Supplier: BioLegend
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Interleukin IL-27 is a heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 P40-related protein) and P28 (a newly discovered IL-12 P35-related protein). It is a member of the IL-6/IL-12 cytokine family and mainly produced by antigen-presenting cells, including macrophages and dendritic cells. IL-27 acts on T cells and NK cells. It has been reported that IL-27 drives rapid clonal expansion of naïve CD4+ T cells, promotes Th1 polarization, and IFN-gamma production in synergy with IL-12. The IL-27 induced Th1 differentiation was mediated by rapid and marked up-regulation of ICAM-1/LFA-1 interaction in a STAT1-dependent manner. IL-27 has an anti-inflammatory function by enhancing Th1 cell differentiation, a potent antitumor activity, through CD8+ T cell and NK cell activation and a potential therapeutic role for autoimmune disease by inhibiting Th-17 development. IL-27 mediates its biological effects through its receptor, WSX-1/T cell cytokine receptor (TCCR), which is homologous to the IL-12Rbeta2 subunit. Protein gp130 serves as a functional signal-transducing molecule for IL-27.
Catalogue number: 516912
Reactivities: Mouse
Hosts: Mouse
Applications: Flow Cytometry, Immunocytochemistry
Size: 500 microg
Clone: MM27-7B1
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4. This Ultra-LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: Mouse IL-27-OVA
Isotype: Mouse IgG2a
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Interleukin-27 p28, IL-27-A, IL-27 subunit alp
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