Home  >  Products  >  Unc-112-related Protein 1 (Unc 112 Related Protein 1, URP1, UNC112A, C20orf42, DTGCU2, Fermitin Family Homolog 1, FERMT1, FLJ20116, FLJ23423, Kindlerin, Kindlin Syndrome Protein, Kindlin-1, KIND1)
Unc-112-related Protein 1 (Unc 112 Related Protein 1, URP1, UNC112A, C20orf42, DTGCU2, Fermitin Family Homolog 1, FERMT1, FLJ20116, FLJ23423, Kindlerin, Kindlin Syndrome Protein, Kindlin-1, KIND1)

Unc-112-related Protein 1 (Unc 112 Related Protein 1, URP1, UNC112A, C20orf42, DTGCU2, Fermitin Family Homolog 1, FERMT1, FLJ20116, FLJ23423, Kindlerin, Kindlin Syndrome Protein, Kindlin-1, KIND1)

Cat no: U1610-01A

Supplier: United States Biological
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URP1, an ortholog of C.elegans UNC-112, is a member of a novel family of PH and FERM-domain containing membrane-associated proteins. A 77kD protein, URP1 is characterized by the presence of a single PH-domain interspersed between two FERM domains and is localized in the cytoplasm. These FERM and PH domains are generally present in proteins involved in intracellular signaling, cytoskeletal organization, cell migration, which indicates a possible role of URP1 in above processes. URP1 has been found to interact with integrins and mediate cell processes dependent on integrin. Up-regulation of URP1 by TGF-alpha and elevated expression levels in lung and colon cancers suggest URP1 as a clinical marker for cancer. Mutations in URP1 gene results in Kindler syndrome, an autosomal recessive dermatosis, characterized by congenital blistering, skin atopy, photosensitivity, skin fragility and scaling. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1610-01A
Reactivities: Human, Bovine, Canine, Porcine, Xenopus/Amphibian, Zebrafish/Fish
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
Alternative names: Fermitin Family Member 1
References: 1. Weinstein, E. J Biochim. Biophys. Acta 1637: 207-216 (2003) 2. Jobard, F et.al Hum. Molec. Genet. 12: 925-935 (2003) 3. Susanne Kloeker et.al J. Biol. Chem., Vol. 279, Issue 8, 6824-6833 (Feb
Additional info: Recognizes human URP1. Species Crossreactivity: chimpanzee, bovine, canine, equine, porcine, xenopus, zebrafish.

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