Home  >  Products  >  UNC5C-like Protein (UNC5CL, MGC34763, Protein unc-5 Homolog C-like, ZU5 and Death Domain-containing Protein, ZUD)
UNC5C-like Protein (UNC5CL, MGC34763, Protein unc-5 Homolog C-like, ZU5 and Death Domain-containing Protein, ZUD)

UNC5C-like Protein (UNC5CL, MGC34763, Protein unc-5 Homolog C-like, ZU5 and Death Domain-containing Protein, ZUD)

Cat no: U1607-50

Supplier: United States Biological
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UNC5CL is a membrane protein belonging to theUNC-5 family with a death domain and a ZU5 domain and is known to interact with p65:RELA and NFKB1. UNC5CL is known to interact with subunit p105 of NF-kappaB and transactivator p65 and is thus involved in inhibition of NF-kappaB activation and NF-kappaB-dependent transcription by inhibiting the binding of NF-kappaB to its target sequence (providing an alternative regulatory mechanism for NF-kappaB-mediated transcription). This regulatory protein sensitizes cells to apopotosis induced by TNF and TRAIL. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Colon tissue Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1607-50
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Unc-5 Homolog C (C. elegans)-like
References: 1. Zhang, J. et al. J. Biol. Chem. 279:17819-17825 (2004).
Additional info: Recognizes human UNC5CL. Species Crossreactivity: chimpanzee. Species sequence homology: bovine, canine, porcine, rhesus monkey.

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