Home  >  Products  >  UNC5C (Unc-5 Homolog C, Netrin Receptor UNC5C Precursor, UNC5H3, Unc-5 Homolog 3, Unc-5 Homolog C )
UNC5C (Unc-5 Homolog C, Netrin Receptor UNC5C Precursor, UNC5H3, Unc-5 Homolog 3, Unc-5 Homolog C )

UNC5C (Unc-5 Homolog C, Netrin Receptor UNC5C Precursor, UNC5H3, Unc-5 Homolog 3, Unc-5 Homolog C )

Cat no: U0893-50

Supplier: United States Biological
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This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. Applications: Suitable for use in ELISA and Immunofluorescence. Other applications not tested. Recommended Dilution: ELISA:1:32000 Immunofluorescence: 50ug/ml stains the islets in Mouse Pancreas after Citrate antigen retrieval. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Peptide Blocking: Corresponding peptide is available for Peptide Blocking studies. See U0893-50-P. Antibody
Catalogue number: U0893-50
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunofluorescence
Size: 100ug
Form: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
References: Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland CR, Goel A. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology 2007 Dec 133 (6): 1849-57.
Additional info: Recognizes human UNC5C. Species sequence homology: mouse, canine.

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