UNC5C (Unc-5 Homolog C, Netrin Receptor UNC5C Precursor, UNC5H3, Unc-5 Homolog 3, Unc-5 Homolog C )

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.\n\nApplications:\nSuitable for use in ELISA and Immunofluorescence. Other applications not tested.\n\nRecommended Dilution:\nELISA:1:32000\nImmunofluorescence: 50ug/ml stains the islets in Mouse Pancreas after Citrate antigen retrieval.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. \n\nPeptide Blocking:\nCorresponding peptide is available for Peptide Blocking studies. See U0893-50-P. Antibody

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SPECIFICATIONS

Catalog Number

U0893-50

Size

100ug

Applications

ELISA, IF

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by peptide affinity chromatography.

Isotype

IgG

References

Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland CR, Goel A. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology 2007 Dec 133 (6): 1849-57.

Additional Info

Recognizes human UNC5C. Species sequence homology: mouse, canine.