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UNC93B1 (Protein Unc-93 Homolog B1, Unc-93B1, hUNC93B1, UNC93, UNC93B)

Cat no: U0893-93A

UNC93B1 (Protein Unc-93 Homolog B1, Unc-93B1, hUNC93B1, UNC93, UNC93B)

UNC93B is a member of a novel hUNC93B-related gene family and encodes a 12-membrane-spanning protein related to unc-93 of Caenorhabditis elegans. The protein is involved in the regulation or coordination of muscle contraction in the worm. The protein is also necessary for TLR signaling and for the presentation and cross-presentation of exogenous antigens. The protein specifically interacts with TLR3, 7, 9, and 13 and introduction of point mutation H412R in UNC93B abolishes these interactions. Mutation in the missense allele of UNC93B, 3d disrupts exogenous antigen presentation and signaling via TLR. The pathological role of the protein has been identified in susceptibility to herpes simplex encephalitis (HSE). In human the protein is expressed in heart and at lower levels in kidney. In mouse the gene is localized in the chromosomal region 19 A.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 3-5ug/ml\nOptimal dilutions to be determined by the researcher. \n\nPositive Control:\nSpleen lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

U0893-93A

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1. Casrouge, A. et al. Science. 314:308-312 (2006). 2. Arnl

Additional Info

Recognizes mouse UNC93B. Species Crossreactivity: human and rat. Species sequence homology: canine, bovine.

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Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

More info

Applications

ELISA

Hosts

Mouse

More info
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