Home  >  Products  >  Uncoupling Protein 1 (Mitochondrial Brown Fat Uncoupling Protein 1, UCP 1, UCP1, UCP-1, UCP, HGNC:12517, Solute Carrier Family 25 Member 7, SLC25A7, Thermogenin)
Uncoupling Protein 1 (Mitochondrial Brown Fat Uncoupling Protein 1, UCP 1, UCP1, UCP-1, UCP, HGNC:12517, Solute Carrier Family 25 Member 7, SLC25A7, Thermogenin)

Uncoupling Protein 1 (Mitochondrial Brown Fat Uncoupling Protein 1, UCP 1, UCP1, UCP-1, UCP, HGNC:12517, Solute Carrier Family 25 Member 7, SLC25A7, Thermogenin)

Cat no: U1620-08B

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Mitochondrial brown fat uncoupling protein 1 (UCP1; also Thermogenin and UCP) is a 33kD member of the mitochondrial carrier family of proteins. Human and mouse UCP1 are both 307aa in length and contain three solcar repetitive regions and six transmembrane segments. UCP1 is found in brown adipose tissue, where it becomes activated by fatty acids and inhibited by nucleotides. It functions as a mitochondrial transporter that creates a proton leak across the inner mitochondrial membrane, uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Human and mouse UCP1 share 79% aa sequence identity. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Adipose lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1620-08B
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Uncoupling Protein 1 (Mitochondrial, Proton Carrier)
References: 1. Ishigaki Y, Katagiri H, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Gao J, Ishihara H, Shimosegawa T, Sakoda H, Asano T, Oka Y. Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. Diabetes. 2005 Feb;54(2):322-32. PMID: 15677488.
Additional info: Recognizes human UCP1.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave