Home  >  Products  >  Uncoupling Protein 1 (Mitochondrial Brown Fat Uncoupling Protein 1, UCP 1, Ucp1, Ucp, AI385626, Solute Carrier Family 25 Member 7, Slc25a7, Thermogenin)
Uncoupling Protein 1 (Mitochondrial Brown Fat Uncoupling Protein 1, UCP 1, Ucp1, Ucp, AI385626, Solute Carrier Family 25 Member 7, Slc25a7, Thermogenin)

Uncoupling Protein 1 (Mitochondrial Brown Fat Uncoupling Protein 1, UCP 1, Ucp1, Ucp, AI385626, Solute Carrier Family 25 Member 7, Slc25a7, Thermogenin)

Cat no: U1620-07A

Supplier: United States Biological
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UCP1 gene encodes a unique mammalian mitochondrial proton carrier that induces heat production in brown adipose tissue by uncoupling respiration from ATP synthesis. Despite its tissue specificity, UCP1 is a member of the mitochondrial carrier protein family, which includes the ATP/ADP translocator, the phosphate, the 2-oxoglutarate/malate and the citrate (tricarboxylate) carriers. Like other mitochondrial carriers, UCP1 is inserted into the inner mitochondrial membrane by means of six alpha-helical hydrophobic domains, each encoded by one of the six exons. In humans, polymorphism in UCP1 gene has been associated with a number of measures of glucose homeostasis and adiposity. Mouse UCP1 gene is located in the chromosomal region 8 38.0 cM. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1620-07A
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: Uncoupling Protein 1 (Mitochondrial, Proton Carrier)
References: 1. Olivier, B. et al. FEBS Letters. 408:39-42 (1997). 2. Michele, MS. et al. BMC Endocrine Disorders. 7:1-10 (2007).
Additional info: Recognizes mouse UCP1. Species Crossreactivity: rat. Species sequence homology: canine, human, rabbit.

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