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Uncoupling Protein 2 (Mitochondrial Uncoupling Protein 2, UCP 2, UCP2, BMIQ4, Solute Carrier Family 25 Member 8, SLC25A8, UCPH)

Cat no: U1621-03

Uncoupling Protein 2 (Mitochondrial Uncoupling Protein 2, UCP 2, UCP2, BMIQ4, Solute Carrier Family 25 Member 8, SLC25A8, UCPH)

UCP2 is a member of the mitochondrial carrier family, having 59% amino-acid identity to UCP1 and has a role in diabetes and obesity. In comparison with UCP1, UCP2 has a greater effect on mitochondrial membrane potential when expressed in yeast. The protein acts as a regulator of mitochondrial ROS production through uncoupling mitochondrial respiration from ATP synthesis. The protein also has a unique role in energy balance, body weight regulation and thermoregulation and their responses to inflammatory stimuli. It is widely expressed in adult human tissues, including tissues rich in macrophages, and is upregulated in white fat in response to fat feeding. UCP2 maps to region of human chromosome 11q13 that has been linked to hyperinsulinaemia and obesity.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:100-1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

U1621-03

Size

100ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Christophe, F. et al. Nature. Genetics. 15:269-272 (1997). 2. Claire, P. et al. The FASEB Journal. 22:9-18 (2008).

Additional Info

Recognizes human UCP2. Species Crossreactivity: mouse and rat. Species sequence homology: bovine, feline, canine, monkey, porcine.

Alternative Names

Uncoupling Protein 2 (Mitochondrial, Proton Carrier)

Read more on Supplier website

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

More info

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

More info

Applications

ELISA

Hosts

Mouse

More info
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