Home  >  Products  >  Uncoupling Protein 2 (Mitochondrial Uncoupling Protein 2, UCP 2, UCP2, BMIQ4, Solute Carrier Family 25 Member 8, SLC25A8, UCPH)
Uncoupling Protein 2 (Mitochondrial Uncoupling Protein 2, UCP 2, UCP2, BMIQ4, Solute Carrier Family 25 Member 8, SLC25A8, UCPH)

Uncoupling Protein 2 (Mitochondrial Uncoupling Protein 2, UCP 2, UCP2, BMIQ4, Solute Carrier Family 25 Member 8, SLC25A8, UCPH)

Cat no: U1621-03

Supplier: United States Biological
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UCP2 is a member of the mitochondrial carrier family, having 59% amino-acid identity to UCP1 and has a role in diabetes and obesity. In comparison with UCP1, UCP2 has a greater effect on mitochondrial membrane potential when expressed in yeast. The protein acts as a regulator of mitochondrial ROS production through uncoupling mitochondrial respiration from ATP synthesis. The protein also has a unique role in energy balance, body weight regulation and thermoregulation and their responses to inflammatory stimuli. It is widely expressed in adult human tissues, including tissues rich in macrophages, and is upregulated in white fat in response to fat feeding. UCP2 maps to region of human chromosome 11q13 that has been linked to hyperinsulinaemia and obesity. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1621-03
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: Uncoupling Protein 2 (Mitochondrial, Proton Carrier)
References: 1. Christophe, F. et al. Nature. Genetics. 15:269-272 (1997). 2. Claire, P. et al. The FASEB Journal. 22:9-18 (2008).
Additional info: Recognizes human UCP2. Species Crossreactivity: mouse and rat. Species sequence homology: bovine, feline, canine, monkey, porcine.

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