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UPK3A, Recombinant, Human, aa19-207, His-tag (Uroplakin-3a, UP3a, Uroplakin III, UPIII, UPK3)

Cat no: 029709

UPK3A, Recombinant, Human, aa19-207, His-tag (Uroplakin-3a, UP3a, Uroplakin III, UPIII, UPK3)

UPK3A belongs to the uroplakin-3 family. Uroplakins (UP) are key components of the urothelium. They are transmembrane proteins that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both belonging to the "tetraspanin" family). All have large luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic portions in their C-termini. UPK3A is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Mutations in this gene may be associated with renal adysplasia.\n\nSource:\nRecombinant corresponding to aa19-207 from human UPK3A, fused to His-tag at N-terminal expressed in E.coli.\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSHMVNLQP QLASVTFATN NPTLTTVALE KPLCMFDSKE ALTGTHEVYL YVLVDSAISR NASVQDSTNT PLGSTFLQTE GGRTGPYKAV AFDLIPCSDL PSLDAIGDVS KASQILNAYL VRVGANGTCL WDPNFQGLCN PPLSAATEYR FKYVLVNMST GLVEDQTLWS DPIRTNQLTP YSTIDTWPGR RSGG\n\nMolecular Weight:\n~23.1kD (MALDI-TOF)\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

029709

Size

50ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 2mM DTT, 20% glycerol, 150mM sodium chloride.

Purity

~90% (SDS-PAGE)

References

1. Shapiro, E., et al. (2000) J. Urol. 164: 1048-1051. 2. Wu, X.R., et al. (1994) 2. J. Biol. Chem. 269:13716-13724.

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Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info
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