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Uracil-DNA Glycosylase 2 (Cyclin-O, Uracil-DNA Glycosylase 2, UDG2, Cyclin-like Uracil-DNA Glycosylase, CCNO, UDG2, UNG2)

Uracil-DNA Glycosylase 2 (Cyclin-O, Uracil-DNA Glycosylase 2, UDG2, Cyclin-like Uracil-DNA Glycosylase, CCNO, UDG2, UNG2)

Cat no: U1900-20C

Supplier: United States Biological
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UNG2 is a 38kD member of the cyclin family, expressed in the nucleus. Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG2 is a major enzyme in base excision repair, excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase, UNG2 is also essential to the generation of strand breaks that initiate class switch recombination. UNG2 is also involved in the innate immune response against retroviral infections, HIV-1 accessory protein Vpr induces the rapid degradation of UNG2. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1900-20C
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Hagen, L. et al. (2006) Genomic uracil and human disease. Exp Cell Res. 312:2666-2672. 2. Krokan, H. et al. (2001) Properties and functions of human uracil-DNA glycosylase from the UNG gene. Prog. Nucleic Acid Res. Mol. Biol. 68:365-386.
Additional info: Recognizes human UNG2. Species Crossreactivity: rat, mouse.

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