Home  >  Products  >  Uracil DNA Glycosylase, CT (UDG, UNG, Uracil DNA Glycosylase 1, UNG 1, UNG1, UNG-1, Uracil DNA Glycosylase 2, DGU, DKFZp781L1143, HIGM4, UNG15)
Uracil DNA Glycosylase, CT (UDG, UNG, Uracil DNA Glycosylase 1, UNG 1, UNG1, UNG-1, Uracil DNA Glycosylase 2, DGU, DKFZp781L1143, HIGM4, UNG15)

Uracil DNA Glycosylase, CT (UDG, UNG, Uracil DNA Glycosylase 1, UNG 1, UNG1, UNG-1, Uracil DNA Glycosylase 2, DGU, DKFZp781L1143, HIGM4, UNG15)

Cat no: U1699-01D

Supplier: United States Biological
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UNG1 is a member of the uracil-DNA glycosylase and cyclin family. Two isoforms of UNG exist, isoform 1 is expressed in the mitochondria of in skeletal muscle, heart and testicles while isoform 2 (UNG2) is more abundant in proliferating tissues and expressed in the nucleus. Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG1 is a major enzyme in base excision repair, excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase, UNG is also essential to the generation of strand breaks that initiate class switch recombination. UNG is also involved in the innate immune response against retroviral infections, HIV-1 accessory protein Vpr induces the rapid degradation of UNG2. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1699-01D
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Hagen, L. et al. (2007) Genomic uracil and human disease. Exp Cell Res. 312:2666-2672. 2. Krokan, H. et al. (2001) Properties and functions of human uracil-DNA glycosylase from the UNG gene. Prog. Nucleic Acid Res. Mol. Biol. 68:365-386. 3. Akbari, M. et al. (2006) Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience. [Epub ahead of print].
Additional info: Recognizes human uracil-DNA glycosylase 1 (UNG1). Species Crossreactivity: mouse, rat.

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