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Urodilatin (Atrial Natriuretic Peptide)

Urodilatin (Atrial Natriuretic Peptide)

Cat no: U1750-01B

Supplier: United States Biological
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Urodilatin is a natriuretic peptide isolated from human urine and belongs to the family of A type natriuretic peptides. Urodilatin is differentially processed to a peptide of 32aa from the same precursor as ANP. It is synthesized in kidney tubular cells and secreted luminally. After secretion from epithelial cells of the distal and/or connecting tubules, Urodilatin interacts downstream at distal segments of the nephron with luminally located receptors whereby it regulates Na(+) and water reabsorption. Thus, the physiological function of the renal Urodilatin system can be described as a paracrine intrarenal regulator for Na(+) and water homeostasis, considering Urodilatin as a real diuretic natriuretic regulatory peptide. Applications: Suitable for use in RIA. Other applications not tested. Recommended Dilutions: RIA: 1:240,000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: U1750-01B
Hosts: Sheep
Size: 20ul
Form: Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with 20ul sterile ddH2O.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Meyer M, Armbruster FP, Maier I, Schwing J, Haller C, Missbichler A et al. Urinary and plasma urodilatin measured by a direct RIA using a highly specific antiserum. Clin Chem 1998; 44 (12):2524-2529
Additional info: Recognizes human Urodilatin. No crossreactivity with human ANP aa1-28, <0.1%; human pro-ANP aa1-30, human pro-ANP aa31-67, human pro-ANP aa79-98, human pro-ANP aa1-98 <0.1%, human BNP <0.1%.

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