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Uroguanylin (Guanylate Cyclase Activator 2B)

Cat no: U2585-01B


Supplier: United States Biological
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Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor GC-C and regulates electrolyte and water transport in intestinal and renal epithelia. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, RIA. Other applications not tested. Recommended Dilution: ELISA: 1:2000 Western Blot: 1:1000 Immunohistochemistry: 1:500-1:1000 RIA: 1:10,000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: U2585-01B
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 20ul
Form: Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute in ddH2O.
P type: Pab
Purity: Serum
References: 1. Hess R, Kuhn M, Schulz-Knappe P, Raida M, Fuchs M, Klodt J, Adermann K, Kaever V, Cetin Y, Forssmann WG. GCAP-II: isolation and characterization of the circulating form of human uroguanylin. FEBS Lett. 1995 Oct 23;374(1):34-8. 2. Ma?gert H-J, Reinecke M, David I, Hans-Rudolf R, Adermann K, Zucht H-D, Hill O, Ru?diger H, Forssmann W-G (1998). Uroguanylin: Gene structure, expression, processing as a peptide hormone, and co-storage with somatostatin in gastrointestinal D-cells. Regul Pept 73(3): 165-176.
Additional info: Recognizes the circulating form of human Uroguanylin.

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