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Urokinase Plasminogen Activator Receptor (Urokinase Plasminogen Activator Surface Receptor, U-PAR, uPAR, Monocyte Activation Antigen Mo3, PLAUR, MO3, UPAR)

Urokinase Plasminogen Activator Receptor (Urokinase Plasminogen Activator Surface Receptor, U-PAR, uPAR, Monocyte Activation Antigen Mo3, PLAUR, MO3, UPAR)

Cat no: U2610-03F

Supplier: United States Biological
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CD87, known as urokinase plasminogen activator-receptor (uPAR), is a 36-68kD single-chain glycophosphotidylinositol (GPI)-anchored glycoprotein. The extracellular region of CD87 consists of three homologous domains, D1, D2, and D3. Membrane-bound and soluble (D2D3) forms of uPAR have been reported. The membrane-bound CD87 is expressed on granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells and keratinocytes. CD87 plays a role in cell adhesion and chemotaxis through binding to B1, B2 and B3 integrins. CD87-bound uPA converts plasminogen to plasmin. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than) 1ug/10e6 cells in 100ul or 100ul whole blood. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U2610-03F
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 25ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by affinity chromatography.
References: 1. Schlossmant, S.F., et al. eds. 1995 Leukocyte Type V. Oxford University Press, Inc., New York. 2. Gadd, S.J., et al., Clin. Exp. Immunol. 80: 252 (1990). 3. Sillaber, C., et al., J. Biol. Chem. 272: 7824 (1997). 4. Beaufort, N., et al., J. Immunol. 172: 540 (2004). 5. Tarui, T., et al., J. Bio. Chem. 276: 3983 (2001). 6. Zola, H., et al., 2007. Leukocyte and Stromal Cell Molecules: The CD Markers. A John Wiley & Sons, Inc., Publication.
Additional info: Recognizes human Urokinase Plasminogen Activator Receptor. Binds to uPA binding-domain.

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