Home  >  Products  >  USP11 (Ubiquitin Carboxyl-terminal Hydrolase 11, Ubiquitin Thiolesterase 11, Deubiquitinating Enzyme 11, Ubiquitin-specific-processing Protease 11, UHX1)
USP11 (Ubiquitin Carboxyl-terminal Hydrolase 11, Ubiquitin Thiolesterase 11, Deubiquitinating Enzyme 11, Ubiquitin-specific-processing Protease 11, UHX1)

USP11 (Ubiquitin Carboxyl-terminal Hydrolase 11, Ubiquitin Thiolesterase 11, Deubiquitinating Enzyme 11, Ubiquitin-specific-processing Protease 11, UHX1)

Cat no: U4100-20F

Supplier: United States Biological
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Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Western Blot: 1-3ug/ml, observed in human testis lysates and in lysates of cell line Jurkat on ~120kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U4100-20F
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S, Hagiwara E, Aoki A, Ishigatsubo Y. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. Biochem J. 2002 Oct 1;367(Pt 1):87-95.
Additional info: Recognizes human USP11.

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