Vacuolar Protein Sorting 26, Homolog A (S. pombe)(VPS26A, Vacuolar Protein Sorting 26 (Vacuolar Protein Sorting 26 (Yeast), VPS 26, VPS26, FLJ12930, Hbeta58, Hbeta58 Homolog, HB58, hVPS26, MGC94168, PEP8A, Vacuolar Protein Sorting 26 A, Vacuolar Protein S

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications have not been tested. \n\nRecommended Dilutions: \nPeptide ELISA Titer: 1:4000\nWestern Blot: 1-3ug/ml ~40kD band observed in Human Kidney lysates (calculated MW of 38.2kD according to NP_004887.2). In transfected HEK293 transiently expressing VPS26A a band of approx. 40kD is observed. This band is not observed in the non-transfected HEK293. \nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

V0649-94A

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by peptide affinity chromatography.

Isotype

IgG

References

1. Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell. 2000 Dec;11(12):4105-16. PMID: 11102511

Additional Info

Recognizes human Vacuolar Protein Sorting 26, Homolog A.This antibody is expected to recognize isoform 1 (NP_004887.2) only. Species sequence homology: mouse, rat, porcine, bovine.

Alternative Names

vacuolar protein sorting 26 A, OTTHUMP00000019721, PEP8A, vacuolar protein sorting 26 homolog A (S. pombe), vacuolar protein sorting 26 homolog A, vacuolar protein sorting 26 (yeast), vacuolar protein sorting 26 (yeast homolog), Hbeta58 homolog, VPS26, Hbeta58, HB58, FLJ12930, vacuolar protein sorting 26 homologue A (yeast), VPS26A