Home  >  Products  >  VAMP 3 (Vesicle Associated Membrane Protein 3, Vesicle-associated Membrane Protein 3, VAMP3, VAMP-3, Cellubrevin, CEB, Synaptobrevin 3, Synaptobrevin-3, SYB3)
VAMP 3 (Vesicle Associated Membrane Protein 3, Vesicle-associated Membrane Protein 3, VAMP3, VAMP-3, Cellubrevin, CEB, Synaptobrevin 3, Synaptobrevin-3, SYB3)

VAMP 3 (Vesicle Associated Membrane Protein 3, Vesicle-associated Membrane Protein 3, VAMP3, VAMP-3, Cellubrevin, CEB, Synaptobrevin 3, Synaptobrevin-3, SYB3)

Cat no: V2024-55B

Supplier: United States Biological
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A novel member of the vesicle-associated membrane protein (VAMP):synaptobrevin family, VAMP-3 is a v-SNARE protein that resides in recycling endosomes and endosome-derived transport vesicles. It colocalizes with endocytosed transferrin receptors and the glucose transporter GLUT4 in adipocytes, and is also present in alpha-granules in platelets. The protein has been implicated in recycling of transferrin receptors to the plasma membrane, secretion of alpha-granules in platelets, recycling of T-cell receptors to the immunological synapses, and membrane trafficking during cell migration. It is a homologue of VAMP-2 and has a broad tissue distribution in humans. Like VAMP-2, it can be cleaved by tetanus toxin, a metallo-endoprotease which blocks synaptic exocytosis. In humans, the VAMP-3 gene is mapped to chromosome 1p36.23. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human, mouse and rat brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: V2024-55B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS containing 0.05% BSA and 0.05% sodium azide
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography
Alternative names: Vesicle-associated Membrane Protein 3 (Cellubrevin)
References: 1. Chuan, H. et al. Experimental Cell Research. 313:3198-3209 (2007).
Additional info: Recognizes human VAMP-3. Species Crossreactivity: mouse and rat. Species sequence homology: New World monkey

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