Vancomycin Hydrochloride

Vancomycin is an aminoglycoside antibiotic, used in the treatment of infections caused by Gram-positive bacteria. vancomycin is not active against Gram-negative bacteria (except some non-gonococcal species of Neisseria). The main target of this antibiotic is the D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors, used by bacteria for constructing their cell walls. This prevents the reaction used to link peptidoglycan precursors together from taking place. Vancomycin binds with the substrate, not the enzyme, in contrast to the way penicillin inhibits peptidoglycan synthesis.\n\nThe large hydrophilic molecule is able to form hydrogen bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Under normal circumstances, this is a five-point interaction. This binding of vancomycin to the D-Ala-D-Ala prevents cell wall synthesis in two ways. It prevents the synthesis of the long polymers of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) that form the backbone strands of the bacterial cell wall, and it prevents the backbone polymers that do manage to form from cross-linking with each other.\n\nPotency (as Vancomycin): (same/more than) 900ug/mg\n\npH (50mg/ml, 25 degrees C): 2.5-4.5\n\nPurity: Purified by chromatography to pass USP\n\nMoisture: ~5%\n\nAppearance: White to light orange with a brown cast powder\n\nSolubility (200mg/4ml dH2O): Faint yellow to dark yellow, clear, complete

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SPECIFICATIONS

Catalog Number

V2049

Size

1g

References

1.Salyers, A., Nature 384: 304 (1996). 2.Brickner, S.J., Chemistry and Industry, 131-125, Feb. 1997. 3. Dutka-Malen, S., et al., Molecular and General Genetics 224: 364-372 (1990). 4. Nicas, T.I., et al., (1996) Antimicrobial Agents and Chemotherapy, 40: 2,194-2,199. 5.Schafer, M., et al., (1996) Structure 4: 1,509-1,515. 6.McKintyre, J., Bull, A.T. and Bunch, A.W. (1996) Biotechnology and Bioengineering 49: 412-420. 7. McIntyre, J., Bunch, A.W. and Bull, A.T. (1997) Vancomycin production by Amycolaptosis orientalis growing in chemostat culture with cell recycle. Submitted for publication.