Vanilloid Receptor 1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1, TRPV1, Capsaicin Receptor, Osm-9-like TRP Channel 1, OTRPC1, VR1)

Supplier:

United States Biological

Cat no: V2075-04J

Vanilloid Receptor 1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1, TRPV1, Capsaicin Receptor, Osm-9-like TRP Channel 1, OTRPC1, VR1)

The transient receptor potential cation channel, subfamily V, member 1 (TRPV1), also known as the capsaicin receptor is a protein which in humans is encoded by the TRPV1 gene. TRPV1 (also called Vanilloid receptor type 1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary afferents, TRPV1 is also expressed in the CNS. Cui M et al. (2006) demonstrate that TRPV1 receptors in the CNS play an important role in pain mediated by central sensitization. And the significant CNS penetration is necessary for a TRPV1 antagonist to produce broad-spectrum analgesia. And TRPV1 also participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 1ug/ml \nImmunohistochemistry (Paraffin): 2ug/ml. Antigen retrieval using heat is required. \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile dH20. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

V2075-04J

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Caterina MJ., et al. Nature 389 (6653): 816-24 (1997). 2. Xue Q., et al. Genomics 76 (1-3): 14-20 (2001). 3. Cui M., et al. J Neurosci. 26(37): 9385-93 (2006). 4. Birder, LA., et al. Naure Neurosci. 5:856-860 (2002).

Additional Info

Recognizes human Vanilloid Receptor 1. \nSpecies Crossreactivity: mouse and rat

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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